Uganda travel to Liberia on Sunday needing to win to keep pace with favourites Senegal at the top of Group J.
The Cranes of Uganda are yet to win in this qualifying campaign, and following draws in their first two matches with Angola and Senegal, now find themselves in second place on two points.
Senegal top the group on four points, and the match in Monrovia will become a pivotal one for Uganda if the Lions of Teranga beat Angola, as expected, on Saturday evening.
Head coach Bobby Williamson surprisingly decided to drop the trio of Hamis Kiiza, Tony Odur and Daniel Serunkuma, who impressed in a recent friendly against Rwanda, for the trip to Liberia.
Williamson has instead opted to include Emma Okwi, Mike Mutyaba, Robert Ssentongo and Geoffrey Massa to face the Lone Stars.
Massa is the likeliest to earn a starting berth following a goal and an assist for his club Yenicami in a 2-1 win in midweek.
Despite the inconsistency of Uganda's attackers, the same cannot be said for their back four, who have been solid for the most part in recent times.
Captain Andy Mwesigwa, and the uncompromising group of Henry Kalungi, Godfrey Walusimbi and Dennis Guma form the solid foundation the Cranes will need if they end up qualifying for Brazil 2014.
Meanwhile, the Lone Stars sit at the bottom of the group on one point after a 3-1 loss to Senegal and a 1-1 draw with Angola and will surely need to win to have any chance at qualifying for the tournament.
Head coach Frank Jericho Nagbe has named 12 professionals in the squad to take on Uganda including Turkish-based winger Tonia Tisdell, with whom many have pinned their hopes of qualification.
The Sanliurfaspor man has the ability to win any game, and will surely play his part if the Liberiana are to emerge triumphant on Sunday.