Olympic sprinters Shelly-Ann Fraser-Pryce and Carmelita Jeter will take part in the British Athletics Grand Prix at the National Indoor Arena on Saturday.
At the 2012 Olympic Games, Fraser-Pryce and Jeter competed for top honours in both the 100m dash and 200m sprint events.
Fraser-Pryce won the gold medal in the 100m race, while Jeter had to settle for second. It was one of the most anticipated races of the games.
While Fraser-Pryce didn't win the 200m event, she still finished ahead of Jeter on the podium. Jeter did manage to get her own back in the 4x100m relay event when the American team won gold.
The rivalry between the two athletes extends as far back as 2009, where Fraser-Pryce won the gold medal at the IAAF World Championships. Jeter had to settle for bronze at that event.
In 2011 it was Jeter who walked away with the gold medal. As the athletics fraternity prepares for the 2013 World Championships, every race that these two top athletes compete in will come under sharp scrutiny, even if it is a 60m dash at an indoor event in Birmingham.
The sprint duo has dominated women's 100m running over the last five seasons with 18 global medals between them.
"Birmingham has been good to me in the past and it was great to run there a few weeks after the Olympics and I'm really looking forward to running there again this weekend," said Fraser-Pryce.
"It will be my first taste of racing indoors and I'm really excited about competing in front of a British crowd again and seeing what I can do over 60m. I have a good start in most of my races so hopefully that will help me competing over a shorter distance," she added.
"Winning Olympic gold was a big achievement for me, and I know that there will be a lot of people who will want to beat me in 2013. However, I'm fully focused on the year ahead, and I'm looking forward to competing once again as I build towards the World Championships this summer."
Jeter, meanwhile, was beaten in Glasgow by Germany's Verena Sailer last month, and is anticipating another tough race when she lines up in the blocks at the NIA this weekend.
"It's always a great race when Shelly-Ann and I compete against each other and I'm sure the visiting fans will see another close one in Birmingham," said Jeter.
"We always seem to bring the best out of each other and I'm looking forward to facing her again and running in front of the passionate British crowd," she added.
"2013 is another important year for me so I would like to perform well indoors, to set me up for the outdoor season and the World Championships in Moscow later on this year. I'm defending champion and I really just want to make sure I'm ready for August."